Age-related decrease in cortical excitability circadian variations during sleep loss and its links with cognition
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چکیده
منابع مشابه
Age-related changes in the circadian modulation of sleep-spindle frequency during nap sleep.
STUDY OBJECTIVES Sleep spindles exhibit a clear circadian modulation in healthy younger people. During the biological night (when melatonin is secreted), spindle density and spindle amplitude are high and spindle frequency and its variability are low, as compared with the biological day. We investigated whether this circadian modulation of spindle characteristics changes with age. DESIGN A 40...
متن کاملCortical excitability and age-related volumetric MRI changes.
OBJECTIVE Normative data on transcranial magnetic stimulation (TMS)-derived measures of cortical excitability in the elderly is sparse. Nevertheless, elderly subjects are included as controls in studies utilizing TMS to investigate disease states. Age-associated increased ventricular cerebrospinal fluid CSF (vCSF) and white matter hyperintensity (WMH) MRI volumes have uncertain significance in ...
متن کاملTreating age-related changes in somatotrophic hormones, sleep, and cognition
Many of the body's systems that function to maintain optimal health and well-being decline with advancing age. Aerobic capacity, muscle mass, and strength all progressively decline. Significant sleep disturbances are associated with increases in morbidity and mortality. Cognition declines, impacting an older individual's ability to function independently. Interventions that could at least stabi...
متن کاملCircadian regulation of human cortical excitability
Prolonged wakefulness alters cortical excitability, which is essential for proper brain function and cognition. However, besides prior wakefulness, brain function and cognition are also affected by circadian rhythmicity. Whether the regulation of cognition involves a circadian impact on cortical excitability is unknown. Here, we assessed cortical excitability from scalp electroencephalography (...
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ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 2019
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2019.02.004